MHC molecules in normal and neoplastic cells
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MHC molecules in normal and neoplastic cells

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Published by Published for the UICC by Wiley-Liss in [New York, N.Y.] .
Written in English


  • Major histocompatibility complex.,
  • HLA histocompatibility antigens.,
  • Oncology, Experimental.,
  • Immunogenetics.,
  • Tumors -- Immunological aspects.

Book details:

Edition Notes

Includes bibliographical references.

Statement[organizers]: Federico Garrido, Francisco Samaniego.
SeriesInternational journal of cancer, supplement -- 6., International journal of cancer -- no. 6.
ContributionsSamaniego, Francisco., Garrido, Federico., International Union against Cancer.
The Physical Object
Pagination162 p. :
Number of Pages162
ID Numbers
Open LibraryOL15168013M

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  MHC class II molecules are responsible for the presentation of exogeneous antigens to helper T cells. The expression of MHC class II molecules is normally restricted to cells of the immune system; nonimmune cells express MHC class II molecules only in abnormal situations, such as viral infection, autoimmune diseases, and :// We conclude that microglia in astrocytic gliomas are well equipped to function as antigen presenting cells. Yet, neoplastic astroglia appear to acquire the capacity to downregulate microglial MHC class II expression and, at the same time, may induce T‐cell clonal anergy through aberrant expression of MHC class II :// Apoptotic cells, in the context of MHC-I, are recognized by dendritic cells activating lymphocytes T-CD8 [, ]. B7 molecules can be included in this mechanism, because both MHC-I and B7 molecules are necessary for T-cell activation [4, 55, 79, 93, , , ]. Considering the role of dendritic cells, the presented results may be useful Natural killer (NK) cells can defend an organism against a variety of threats, probably using several different strategies to discriminate between normal and aberrant cells. According to the 'missing self' hypothesis, one function of NK cells is to recognize and eliminate cells that fail to express self major histocompatibility complex (MHC

Results: MHC class I molecules are expressed by the entire spectrum of different stages of both human and mouse prostate tumor cells. Additionally, cells of the hematopoietic lineage, dispersed in the tumor microenvironment, showed significant expression of MHC class II molecules. Human prostate tumors also show a significant infiltrate of CD3 Recent evidence suggests that the expression of abnormally high amounts of major histocompatibility complex (MHC) class I molecules may be a feature of at least some kinds of transformed cells. To investigate this aspect of neoplastic transformation we studied the expression of MHC class I antigens in an experimental model of normal, tumor-derived, and virus-transformed thyroid epithelial cell   The presence of foreign MHC molecules in a host is extremely inflammatory and the host immune system will potently attack cells which display foreign MHC alleles. Consequently, transplantation of organs or tissues which possess different MHC alleles into a host can result in Hyperacute Rejection and Acute Rejection of the organ or Cruz, I., Meijer, C., Walboomers, J. et al. Lack of MHC class I surface expression on neoplastic cells and poor activation of the secretory pathway of cytotoxic cells in oral squamous cell ://

As discussed in Cellular Defenses, major histocompatibility complex (MHC) molecules are expressed on the surface of healthy cells, identifying them as normal and “self” to natural killer (NK) molecules also play an important role in the presentation of foreign antigens, which is a critical step in the activation of T cells and thus an important mechanism of the adaptive immune   MHC I molecules are found on all nucleated cells; they present normal self-antigens as well as abnormal or nonself pathogens to the effector T cells involved in cellular immunity. In contrast, MHC II molecules are only found on macrophages, dendritic cells, and B cells ; they present abnormal or nonself pathogen antigens for the initial A clear correlation between MHC class I expression and the relative proportion of NK cells/CTLs was not found. This study shows that the majority of OSCCs show weak or absent expression of MHC class I molecules on the cell surface, possibly due to alterations in the normal beta2-m ://   The major histocompatibility complex (MHC) is a large locus on vertebrate DNA containing a set of closely linked polymorphic genes that code for cell surface proteins essential for the adaptive immune locus got its name because it was discovered in the study of tissue compatibility upon transplantation. Later studies revealed that tissue rejection due to incompatibility is an